4SC-202 free base ( 4SC202; 4SC-202; 4SC 202; domatinostat )

产品货号. M16538 CAS No. 910462-43-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

4SC-202 free base
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively.
产品描述

4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory activity against Lysine specific demethylase 1 (LSD1). Phase 1.
同义词

4SC202; 4SC-202; 4SC 202; domatinostat
通路

Cell Cycle/DNA Damage
靶点

HDAC
受体

HDAC3; HDAC2; HDAC1
研究领域

Cancer
适应症

——

CAS Number

910462-43-0
分子量

447.51
分子式

CHNOS
纯度

>98%(HPLC)
溶解度

DMSO:82 mg/mL (183.2 mM);Ethanol:<1 mg/mL;Water:<1 mg/mL
SMILES

O=C(NC1=CC=CC=C1N)/C=C/C2=CN(S(=O)(C3=CC=C(C4=CN(C)N=C4)C=C3)=O)C=C2.O=S(C5=CC=C(C)C=C5)(O)=O
化学全称

(E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide.

1.Henning SW, et al. 22nd EORTC-NCI-AACR symposium. 2010. Abstract # 178.

计算器

产品手册

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